Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge.
Bhuwan Khatri ChhetriRiya BhanushaliYifan LiangMarisa R CepedaAdi Kula NiradininocoKaty SoapiBaojie WanMallique QaderScott G FranzblauJulia KubanekPublished in: Journal of natural products (2023)
Tuberculosis (TB) is a dreadful infectious disease and a leading cause of mortality and morbidity worldwide, second in 2020 only to severe acute respiratory syndrome 2 (SARS-Cov-2). With limited therapeutic options available and a rise in multidrug-resistant tuberculosis cases, it is critical to develop antibiotic drugs that display novel mechanisms of action. Bioactivity-guided fractionation employing an Alamar blue assay for Mycobacterium tuberculosis strain H37Rv led to the isolation of duryne ( 13 ) from a marine sponge Petrosia sp. sampled in the Solomon Islands. Additionally, five new strongylophorine meroditerpene analogues ( 1 - 5 ) along with six known strongylophorines ( 6 - 12 ) were isolated from the bioactive fraction and characterized using MS and NMR spectroscopy, although only 13 exhibited antitubercular activity.
Keyphrases
- mycobacterium tuberculosis
- infectious diseases
- sars cov
- multidrug resistant
- pulmonary tuberculosis
- mass spectrometry
- multiple sclerosis
- ms ms
- gram negative
- high throughput
- acinetobacter baumannii
- respiratory syndrome coronavirus
- case report
- molecular docking
- light emitting
- emergency department
- pseudomonas aeruginosa
- respiratory tract
- structure activity relationship
- cystic fibrosis
- drug induced