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Quantitative tissue analysis and role of myeloid cells in non-small cell lung cancer.

Brian S HenickFranz Villaroel-EspindolaIla DatarMiguel F SanmamedJovian YuShruti S DesaiAlice LiAdam Aguirre-DuclerKonstantinos SyrigosDavid L RimmLieping ChenRoy S HerbstKurt A Schalper
Published in: Journal for immunotherapy of cancer (2022)
NSCLCs display an unfavorable myeloid immune contexture relative to non-tumor lung and exhibit distinct myeloid-cell profiles across histologies and presence of major oncogenic driver-mutations. Elevated M1-like stromal proinflammatory myeloid cells are prognostic in lung ADC, but not in SCC.
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