Heme-induced corpus cavernosum relaxation and its implications for priapism in sickle cell disease: a mechanistic insight.

Dalila Andrade PereiraDanillo Andrade PereiraTammyris Helena Rebecchi SilveiraFabiano Beraldi CalmasiniArthur L BurnettFernando Ferreira CostaFábio Henrique Silva

Published in: Andrology (2024)

The HO-CO-sGC-cGMP pathway appears to play a crucial role in promoting CC relaxation. Our study provides novel insight into the role of group heme in CC relaxation and its potential contribution to priapism in SCD. Heme may serve as a pharmacological target for new therapies to prevent priapism.

Keyphrases

sickle cell disease
single molecule
nitric oxide
high glucose
diabetic rats
drug induced
protein kinase
pi k akt
stress induced