Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide.
Philip PickfordMaria LuceyZijian FangStavroula BitsiJorge Bernardino de La SernaJohannes BroichhagenDavid J HodsonJames MinnionGuy A RutterStephen R BloomAlejandra TomasBen JonesPublished in: British journal of pharmacology (2020)
Changes to the C-terminus of exendin-4 affect signalling potency and GLP-1 receptor trafficking via mechanisms unrelated to GLP-1 receptor occupancy. These differences were associated with changes in their ability to control blood glucose and therefore may be therapeutically relevant.