Quantification of Thioguanine in DNA Using Liquid Chromatography-Tandem Mass Spectrometry for Routine Thiopurine Drug Monitoring in Patients With Pediatric Acute Lymphoblastic Leukemia.
Rihwa ChoiMi Ryung ChunJisook ParkJi Won LeeHee Young JuHee Won ChoJu Kyung HyunHong Hoe KooEun Sang YiSoo-Youn LeePublished in: Annals of laboratory medicine (2021)
This simple and sensitive method for measuring DNA-TG level can improve therapeutic drug monitoring for thiopurine treatment.
Keyphrases
- liquid chromatography tandem mass spectrometry
- acute lymphoblastic leukemia
- circulating tumor
- simultaneous determination
- cell free
- single molecule
- ms ms
- solid phase extraction
- nucleic acid
- allogeneic hematopoietic stem cell transplantation
- clinical practice
- combination therapy
- mass spectrometry
- young adults
- replacement therapy
- tandem mass spectrometry