Interleukin-33 facilitates liver regeneration through serotonin-involved gut-liver axis.
Yankai WenChristoph EmontzpohlLong XuConstance Lynn AtkinsJong-Min JeongYang YangKangho KimChuan WuShizuo AkiraCynthia JuPublished in: Hepatology (Baltimore, Md.) (2022)
Our study identified that IL-33 is pro-regenerative in a noninjurious model of liver resection. The underlying mechanism involved IL-33/ST2-induced increase of serotonin release from enterochromaffin cells to portal blood and subsequent HTR2A/p70S6K activation in hepatocytes by serotonin. The findings implicate the potential of targeting the IL-33/ST2/serotonin pathway to reduce the risk of post-hepatectomy liver failure and small-for-size syndrome.
Keyphrases
- liver failure
- stem cells
- induced apoptosis
- hepatitis b virus
- mesenchymal stem cells
- drug induced
- high glucose
- liver injury
- cancer therapy
- cell cycle arrest
- cell therapy
- drug delivery
- cell proliferation
- case report
- oxidative stress
- human health
- risk assessment
- liver metastases
- endothelial cells
- endoplasmic reticulum stress
- stress induced