Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai .
Jiarui ZhangHuixue MaShuangshuang JinXuehuan LiuLei LiZhaonan LiuGuo-Qiang LiPinglin LiPublished in: Marine drugs (2023)
Seven new lobane diterpenoids, namely, lobocatalens A-G ( 1 - 7 ), were isolated from the Xisha soft coral Lobophytum catalai . Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A ( 1 ) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line.
Keyphrases
- endothelial cells
- papillary thyroid
- systematic review
- electronic health record
- density functional theory
- molecular dynamics simulations
- induced pluripotent stem cells
- genome wide
- high resolution
- molecular docking
- big data
- ionic liquid
- childhood cancer
- mass spectrometry
- dna methylation
- machine learning
- human immunodeficiency virus
- data analysis
- hepatitis c virus
- young adults
- lymph node metastasis
- antiretroviral therapy