A diagnostic index based on quantitative susceptibility mapping and voxel-based morphometry may improve early diagnosis of Alzheimer's disease.

Ryota SatoKohsuke KudoNiki UdoMasaaki MatsushimaIchiro YabeAkinori YamaguchiKhin Khin ThaMakoto SasakiMasafumi HaradaNoriyuki MatsukawaTomoki AmemiyaYasuo KawataYoshitaka BitoHisaaki OchiToru Shirai

Published in: European radiology (2022)

• We developed a novel diagnostic index for Alzheimer's disease based on quantitative susceptibility mapping (QSM) and voxel-based morphometry (VBM). • QSM and VBM images can be acquired simultaneously in a single sequence with little increasing scan time. • In this preliminary study, the proposed diagnostic index improved the discriminative performance between mild cognitive impairment and normal control groups compared with the conventional VBM-based index.

Keyphrases

mild cognitive impairment
cognitive decline
high resolution
computed tomography
deep learning
magnetic resonance imaging
mass spectrometry
convolutional neural network
optical coherence tomography
magnetic resonance