Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives.
Yi GuoChanjun LuKe HuChuanqi CaiWeici WangPublished in: Biomolecules (2022)
Cardiovascular diseases (CVDs) are still a major cause of global mortality and disability, seriously affecting people's lives. Due to the severity and complexity of these diseases, it is important to find new regulatory mechanisms to treat CVDs. Ferroptosis is a new kind of regulatory cell death currently being investigated. Increasing evidence showed that ferroptosis plays an important role in CVDs, such as in ischemia/reperfusion injury, heart failure, cardiomyopathy, and atherosclerosis. Protecting against CVDs by targeting ferroptosis is a promising approach; therefore, in this review, we summarized the latest regulatory mechanism of ferroptosis and the current studies related to each CVD, followed by critical perspectives on the ferroptotic treatment of CVDs and the future direction of this intriguing biology.
Keyphrases
- cell death
- cardiovascular disease
- heart failure
- current status
- cell cycle arrest
- ischemia reperfusion injury
- transcription factor
- multiple sclerosis
- cardiovascular events
- oxidative stress
- type diabetes
- left ventricular
- coronary artery disease
- atomic force microscopy
- metabolic syndrome
- cardiovascular risk factors
- signaling pathway
- cell proliferation
- acute heart failure
- high speed