Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects.

Cajsa DavegårdhChrista BroholmAlexander PerfilyevTora HenriksenSonia García-CalzónLone PeijsNinna Schiøler HansenPetr VolkovRasmus KjøbstedJørgen F P WojtaszewskiMaria PedersenBente Klarlund PedersenDov B BallakCharles A DinarelloBas HeinhuisLeo A B JoostenEmma NilssonAllan VaagCamilla ScheeleCharlotte Ling

Published in: BMC medicine (2017)

Our study identifies IL-32 as a novel myogenic regulator, provides a comprehensive map of the dynamic epigenome during differentiation of human muscle stem cells and reveals abnormal epigenetic changes in obesity.

Keyphrases

stem cells
skeletal muscle
dna methylation
endothelial cells
insulin resistance
metabolic syndrome
weight loss
type diabetes
gene expression
induced pluripotent stem cells
adipose tissue
genome wide
cell therapy
weight gain
obese patients
high fat diet induced