Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations.
Lina-Marcela Diaz-GalloVilija OkeEmeli LundströmKerstin ElvinYee Ling WuSusanna EketjällAgneta ZickertJohanna T GustafssonAndreas JönsenDag LeonardDaniel J BirminghamGunnel NordmarkAnders A BengtssonLars RönnblomIva GunnarssonChack-Yung YuLeonid PadyukovElisabet SvenungssonPublished in: ACR open rheumatology (2021)
Our findings suggest that four fairly distinct subgroups can be identified on the basis of the autoantibody profile in SLE. These four SLE subgroups differ regarding associations with HLA-DRB1 alleles and immunological and clinical features, suggesting dissimilar disease pathways.