Serum Proteomics Distinguish Subtypes of NMO Spectrum Disorder and MOG Antibody-Associated Disease and Highlight Effects of B-Cell Depletion.
Saurabh GawdeNadja SiebertKlemens RuprechtGaurav KumarRose M KoKaylea MasseyJoel M GuthridgeYang Mao-DraayerPatrick SchindlerMaria HastermannGabriel PardoFriedemann PaulRobert C AxtellPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
Proteomic profiles show unique biological pathways that distinguish AQP4-NMOSD, MOGAD, or SN-NMOSD. Furthermore, BCD uniquely affects inflammatory pathways in each disease type, providing an explanation for the disparate therapeutic response in AQP4-NMOSD and MOGAD.