Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice.
Xin-Xin GuanHui-Hui YangWen-Jing ZhongJia-Xi DuanChen-Yu ZhangHui-Ling JiangYang XiangYong ZhouCha-Xiang GuanPublished in: Molecular medicine (Cambridge, Mass.) (2022)
Our study first reports that the activation of Fn14 aggravates ALI by amplifying the activation of NLRP3 inflammasome. Therefore, blocking Fn14 may be a potential way to treat ALI.
Keyphrases
- nlrp inflammasome
- liver failure
- signaling pathway
- respiratory failure
- emergency department
- high fat diet induced
- metabolic syndrome
- drug induced
- adverse drug
- human health
- skeletal muscle
- hepatitis b virus
- climate change
- extracorporeal membrane oxygenation
- electronic health record
- acute respiratory distress syndrome