Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma.

Frank JühlingNourdine HamdaneEmilie CrouchetShen LiHoussein El SaghireAtish MukherjiNaoto FujiwaraMarine A OudotChristine ThumannAntonio SavianoArmando Andres Roca SuarezKaku GotoRicard MasiaMozhdeh SojoodiGunisha AroraHiroshi AikataAtsushi OnoParissa TabrizianMyron SchwartzStephen J PolyakIrwin DavidsonChristian SchmidlChristoph BockCatherine SchusterKazuaki ChayamaPatrick PessauxKenneth K TanabeYujin HoshidaMirjam B ZeiselFrançois Ht DuongBryan C FuchsThomas F Baumert

Published in: Gut (2020)

Our results unravel the functional relevance of metabolic and virus-induced epigenetic alterations for pathogenesis of HCC development and identify chromatin readers as targets for chemoprevention in patients with chronic liver diseases.

Keyphrases

gene expression
dna methylation
genome wide
high glucose
sars cov
dna damage
diabetic rats
transcription factor
cancer therapy
drug induced