Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients.

Sireesha ManneNaveen KondruHuajun JinGeidy E SerranoVellareddy AnantharamArthi KanthasamyCharles H AdlerThomas G BeachAnumantha G Kanthasamy

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Our blinded study results clearly demonstrate the feasibility of using skin tissues for clinical diagnosis of PD by detecting pathological αSyn. Moreover, this peripheral biomarker discovery study may have broader translational value in detecting misfolded proteins in skin samples as a longitudinal progression marker. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

soft tissue
gene expression
ejection fraction
wound healing
small molecule
prognostic factors
clinical trial
study protocol