A novel bispecific DARPin targeting FcγRIIB and FcεRI-bound IgE inhibits allergic responses.
F ZellwegerP GasserD BriggerP BuschorM VogelAlexander EggelPublished in: Allergy (2017)
The described bispecific DARPin protein has the ability to co-ligate FcγRIIB with FcεRI-bound IgE on allergic effector cells and represents an efficient dual-modality to interfere with allergic hypersensitivity reactions.