Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach.

Aiichiro NagakiHiroki YamashitaKatsuyuki HiroseYuta TsuchihashiJun-Ichi Yoshida

Published in: Angewandte Chemie (International ed. in English) (2019)

Flash chemistry based on flow microreactor systems allowed alkyllithiums bearing electrophilic functional groups to be successfully generated and used for subsequent reactions. The series of reactions with high reactivity was achieved by extremely accurate control over residence time in a controlled and selective manner.

Keyphrases

drug discovery
high resolution
capillary electrophoresis