Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the NRF2/BNIP3/PINK1 Axis in the MPP + Iodide-Induced Parkinson's Disease Mice Model.

Poojitha PinjalaKamatham Pushpa TryphenaAmrita KulkarniPrince Giri GoswamiDharmendra Kumar Khatri

Published in: Journal of Alzheimer's disease reports (2024)

DMF confers neuroprotection by activating the BNIP3/PINK1/Parkin pathway, enhancing the autophagosome formation via LC3, and improving mitophagy in PD models, and could be a potential therapeutic option in PD.

Keyphrases

cerebral ischemia
diabetic rats
oxidative stress
high glucose
nlrp inflammasome
signaling pathway
brain injury
high fat diet induced
subarachnoid hemorrhage
simultaneous determination
blood brain barrier
wild type