Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats.

Qiquan ZhuBudbazar EnkhjargalLei HuangTongyu ZhangChengmei SunZhiyi XiePei WuJun MoJiping TangZongyi XieArne P Neyrinck

Published in: Journal of neuroinflammation (2018)

Taken together, exogenous Aggf1 treatment attenuated neuroinflammation and BBB disruption, improved neurological deficits after SAH in rats, at least in part through the PI3K/Akt/NF-κB pathway.

Keyphrases

pi k akt
cerebral ischemia
subarachnoid hemorrhage
signaling pathway
blood brain barrier
lps induced
brain injury
traumatic brain injury
cell proliferation
cell cycle arrest
lipopolysaccharide induced
inflammatory response
cognitive impairment
oxidative stress
combination therapy
immune response
toll like receptor