Chitosan-graphene quantum dot based active film as smart wound dressing.
Elisabete Regina Fernandes Ramos RibeiroLuana Barbosa CorreaEduardo Ricci-JuniorPedro Filho Noronha SouzaClenilton Costa Dos SantosAlan Silva de MenezesElaine Cruz RosasPrapanna BhattaraiMohamed F AttiaLin ZhuLuciana Magalhães Rebelo AlencarRalph Santos-OliveiraPublished in: Journal of drug delivery science and technology (2022)
Graphene quantum dots (GQDs), are biocompatible materials, with mechanical strength and stability. Chitosan, has antibacterial and anti-inflammatory properties, and biocompatibility. Wound healing is a challenging process especially in chronic diseases and infection. In this study, films consisting of chitosan and graphene quantum dots were developed for application in infected wounds. The chitosan-graphene films were prepared in the acidic solution followed by slow solvent evaporation and drying. The chitosan-graphene films were characterized by the scanning electron microscopy, x-ray diffraction, atomic force microscopy, Raman spectroscopy and thermogravimetric analysis. The films' was evaluated by the wound healing assays, hemolytic potential, and nitrite production, cytokine production and swelling potential. The obtained films were flexible and well-structured, promoting cell migration, greater antibacterial activity, lower hemolytic activity, and maintaining wound moisture. Our data suggested that the use of graphene quantum dot-containing chitosan films would be an efficient and promising way in combating wounds.
Keyphrases
- wound healing
- room temperature
- carbon nanotubes
- ionic liquid
- electron microscopy
- quantum dots
- cell migration
- drug delivery
- raman spectroscopy
- atomic force microscopy
- anti inflammatory
- high resolution
- walled carbon nanotubes
- nitric oxide
- magnetic resonance imaging
- high speed
- electronic health record
- machine learning
- computed tomography
- reduced graphene oxide