Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor.

Ping WangYan CuiJing WangDonghua LiuYue TianKai LiuXue WangLin LiuYu HeYufeng PeiLi LiLiying SunZhijun ZhuDehua ChangJidong JiaHong You

Published in: Stem cell research & therapy (2022)

MSCs are comparable to NAC against APAP-induced liver failure by secreting HGF with less regenerative retardation concerns, thus facilitating the application of MSCs in clinical therapy for APAP liver failure.

Keyphrases

liver failure
mesenchymal stem cells
growth factor
drug induced
liver injury
umbilical cord
hepatitis b virus
cell therapy
bone marrow
high glucose
diabetic rats
stem cells
endothelial cells
oxidative stress