Donepezil-Loaded Nanocarriers for the Treatment of Alzheimer's Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles.

Rummenigge Oliveira SilvaHermine CounilJean-Michel RabanelMohamed HaddadCharlotte ZaouterMohamed Raâfet Ben KhedherShunmoogum A PattenCharles Ramassamy

Published in: International journal of nanomedicine (2024)

The EVs-DNZ formulation was more efficient to inhibit the AChE enzyme activity in the zebrafish larvae head. Thus, the bioinspired delivery system (EVs) is a promising alternative strategy for brain-targeted delivery by substantially improving the activity of DNZ for the treatment of AD.

Keyphrases

drug delivery
cancer therapy
cognitive decline
multiple sclerosis
white matter
mild cognitive impairment