Neutrophil Phospholipase Cγ2 Drives Autoantibody-Induced Arthritis Through the Generation of the Inflammatory Microenvironment.

Krisztina Futosi Orsolya Kása Kata P Szilveszter Attila Mócsai

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Neutrophil PLCγ2 is critical for arthritis development, supposedly through the generation of the inflammatory microenvironment. PLCγ2-expressing neutrophils exert complex indirect effects on other inflammatory cells. PLCγ2-targeted therapies may provide particular benefit in inflammatory diseases with a major neutrophil component.

Keyphrases

oxidative stress
rheumatoid arthritis
stem cells
induced apoptosis
high glucose
cell cycle arrest
drug induced
cell proliferation
signaling pathway
wild type