Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Wenliang ZhangYaoshan DunBaiyang YouLing QiuJeffrey W Ripley-GonzalezJing ChengSiqian FuCui LiSuixin LiuPublished in: BMJ open diabetes research & care (2022)
This study showed that TMZ, like exercise, brought about marked improvements to HFD-induced skeletal muscle IR through TMZ, a common pathway with exercise in the form of Nrf2, regulating oxidative stress. We provide new evidence to support the use of TMZ for diabetes treatment.
Keyphrases
- skeletal muscle
- insulin resistance
- oxidative stress
- high intensity
- diabetic rats
- high fat diet
- high fat diet induced
- type diabetes
- physical activity
- resistance training
- adipose tissue
- metabolic syndrome
- cardiovascular disease
- glycemic control
- polycystic ovary syndrome
- high glucose
- dna damage
- ischemia reperfusion injury
- endothelial cells
- drug induced