Inhibition of mitochondrial activity ameliorates atherosclerosis in ApoE-/- mice via suppressing vascular smooth cell activation and macrophage foam cell formation.

Weiwei XiaYuanyuan LiMengying WuJie YinYue ZhangHongbing ChenSongming HuangZhanjun JiaAihua Zhang

Published in: Journal of cellular biochemistry (2019)

Inhibition of mitochondrial activity could significantly attenuate atherosclerosis possibly by modulating CD36-mediated macrophage foam cell formation and PI3K/AKT signaling pathway-associated VSMC activation. Targeting mitochondrial activity might be the potential therapeutic strategy for atherosclerosis.

Keyphrases

signaling pathway
pi k akt
single cell
oxidative stress
cardiovascular disease
cell proliferation
type diabetes
stem cells
induced apoptosis
cell cycle arrest
high fat diet
mouse model
bone marrow
drug delivery
nk cells