Activity of amlodipine against Staphylococcus aureus : association with oxacillin and mechanism of action.
Amanda Dias BarbosaLívia Gurgel do Amaral Valente SáJoão Batista de Andrade NetoDaniel Sampaio RodriguesVitória Pessoa de Farias CabralLara Elloyse Almeida MoreiraIgor G AguiarHélcio Silva Dos SantosBruno Coêlho CavalcantiEmanuelle Machado MarinhoJacilene SilvaHemerson Iury Ferreira MagalhãesManoel O MoraesHélio Vitoriano Nobre JúniorCecília Rocha da SilvaPublished in: Future microbiology (2023)
Aim: This study was designed to evaluate the in vitro antimicrobial activity of amlodipine against Staphylococcus aureus strains. Materials & methods: The antimicrobial activity of amlodipine was evaluated by the broth microdilution method and its interaction with oxacillin was evaluated by checkerboard assay. The possible mechanism of action was evaluated by flow cytometry and molecular docking techniques. Results: Amlodipine showed activity against S. aureus between 64 and 128 μg/ml, in addition to showing synergism in approximately 58% of the strains used. Amlodipine also showed good activity against forming and mature biofilms. The possible mechanism of action may be attributed to its ability to lead to cell death. Conclusion: Amlodipine has antibacterial activity against S. aureus .