Mer tyrosine kinase as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease.

Lucrezia RovatiNaoki KanekoFederica PedicaAntonella MonnoTakashi MaeharaCory PeruginoMarco LanzillottaSimone PecettaJohn H StoneClaudio DoglioniAngelo A ManfrediShiv PillaiEmanuel Della-Torre

Published in: Rheumatology (Oxford, England) (2021)

The MerTK-ProS1 axis is activated in IgG4-RD lesions, possibly leading to persistent stimulation of processes involved in the resolution of inflammation and tissue fibrosis.

Keyphrases

tyrosine kinase
oxidative stress
epidermal growth factor receptor
single molecule
liver fibrosis