pCAD refers to coronary artery disease (CAD) occurring before the age of 65 years in women and 55 years in men. Both genetic and non-genetic risk factors may contribute to the onset of pCAD. Recent advances in the genetic epidemiology of pCAD have revealed the importance of both monogenic and polygenic contributions to pCAD. Familial hypercholesterolemia (FH) is the most common monogenic disorder associated with atherosclerotic pCAD. However, clinical overreliance on monogenic genes can result in overlooked genetic causes of pCAD, especially polygenic contributions. Non-genetic factors, notably smoking and drug use, are also important contributors to pCAD. Cigarette smoking has been observed in 25.5% of pCAD patients relative to 12.2% of non-pCAD patients. Finally, myocardial infarction (MI) associated with spontaneous coronary artery dissection (SCAD) may result in similar clinical presentations as atherosclerotic pCAD. Recognizing the genetic and non-genetic causes underlying pCAD is important for appropriate prevention and treatment. Despite recent progress, pCAD remains incompletely understood, highlighting the need for both awareness and research.
Keyphrases
- coronary artery disease
- genome wide
- end stage renal disease
- risk factors
- coronary artery
- copy number
- newly diagnosed
- ejection fraction
- chronic kidney disease
- heart failure
- peritoneal dialysis
- prognostic factors
- pregnant women
- percutaneous coronary intervention
- cardiovascular events
- single cell
- atrial fibrillation
- adipose tissue
- patient reported outcomes
- metabolic syndrome
- skeletal muscle