Antiretroviral drug exposure in urethral and glans surface sampling of the penis.

Richard E HaalandJeffrey FountainChuong DinhL Davis LupoAmy MartinChristopher Conway-WashingtonLaShonda HallColleen F KelleyJ Gerardo Garcia-LermaWalid Heneine

Published in: The Journal of antimicrobial chemotherapy (2021)

We document ARV dosing in the urethra and on the glans surface with high drug concentrations noted for emtricitabine and darunavir and lower tenofovir and elvitegravir concentrations. Data suggest a potential protective role of urethral emtricitabine or darunavir against penile HIV acquisition.

Keyphrases

antiretroviral therapy
hiv infected patients
hiv infected
hiv positive
human immunodeficiency virus
hiv aids
urinary incontinence
hepatitis c virus
electronic health record
adverse drug
big data
emergency department
drug induced
hiv testing
south africa
human health
machine learning
data analysis
climate change