IMMUNEPOTENT CRP induces DAMPS release and ROS-dependent autophagosome formation in HeLa and MCF-7 cells.

Ana Carolina Martínez-TorresAlejandra Reyes-RuizKenny Misael Calvillo-RodriguezKarla Maria Alvarez-ValadezAshanti C Uscanga-PalomequeReyes S Tamez-GuerraCristina Rodríguez-Padilla

Published in: BMC cancer (2020)

ICRP induces a non-apoptotic cell death that requires an oxidative stress to take place, involving mitochondrial damage, ROS-dependent autophagosome formation, ER stress and DAMPs' release. These data indicate that ICRP could work together with classic apoptotic inductors to attack cancer cells from different mechanisms, and that ICRP-induced cell death might activate an immune response against cancer cells.

Keyphrases

cell death
cell cycle arrest
oxidative stress
diabetic rats
induced apoptosis
immune response
dna damage
ischemia reperfusion injury
high glucose
breast cancer cells
big data
signaling pathway
machine learning
cell proliferation
endothelial cells
data analysis
pi k akt
deep learning