Nickel-catalyzed direct methylation of arylphosphines via carbon-phosphorus bond cleavage using AlMe 3 .

Takuya IgarashiRyoma ShimazumiNaoto Chatani Mamoru Tobisu

Published in: Chemical communications (Cambridge, England) (2023)

We report herein on the nickel-catalyzed methylation of arylphosphines using AlMe 3 via the cleavage of unactivated C(aryl)-P bonds. This reaction allows for the direct, catalytic substitution of an aryl group on a phosphorus center with a methyl group. This catalytic methylation can proceed, when phosphine oxides and sulfides are used as a substrate.

Keyphrases

genome wide
dna methylation
room temperature
dna binding
sewage sludge
reduced graphene oxide
carbon nanotubes
oxide nanoparticles
crystal structure
gene expression
metal organic framework
transcription factor
transition metal
anaerobic digestion