Iridium-Catalyzed Diastereo- and Enantioselective [4 + 1] Cycloaddition of Hydroxyallyl Anilines with Sulfoxonium Ylides.
Chunlan HeYaping TangShengbiao TangJiangtao SunPublished in: Organic letters (2023)
We present here an iridium-catalyzed diastereo- and enantioselective [4 + 1] cycloaddition reaction of hydroxyallyl anilines with sulfoxonium ylides under mild reaction conditions, leading to 3-vinyl indolines in moderate to good yields with excellent enantioselectivities. Control experiments disclosed a plausible reaction mechanism.