Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis.
Susen BeckerBenedict Kinny-KösterMichael BartelsMarkus ScholzDaniel SeehoferThomas BergCornelius EngelmannJoachim ThieryUta CeglarekThorsten KaiserPublished in: PloS one (2017)
Low plasma S1P concentrations are highly significantly associated with prognosis in end-stage liver disease. This association is independent of the stage of liver disease. Further studies should be performed to investigate S1P, its role in the pathophysiology of liver diseases and its potential for therapeutic interventions.