Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach.
Michael M MendelsonRiccardo E MarioniRoby JoehanesChunyu LiuÅsa K HedmanStella AslibekyanEllen W DemerathWeihua GuanDegui ZhiChen YaoTianxiao HuanChristine WillingerBrian H ChenPaul CourchesneMichael MulthaupMarguerite R IrvinAriella T CohainEric E SchadtMegan L GroveJan BresslerKari NorthJohan SundströmStefan GustafssonSonia ShahAllan F McRaeSarah E HarrisJude GibsonPaul RedmondJanie CorleyLee MurphyJohn M StarrErica L KleinbrinkLeonard LipovichPeter M VisscherNaomi R WrayRonald M KraussM Daniele FallinAndrew FeinbergDevin M AbsherMyriam FornageJames S PankowLars LindCaroline FoxErik IngelssonDonna K ArnettEric BoerwinkleLiming LiangDaniel LevyIan J DearyPublished in: PLoS medicine (2017)
We present robust associations of BMI with differential DNA methylation at numerous loci in blood cells. BMI-related DNA methylation and gene expression provide mechanistic insights into the relationship between DNA methylation, obesity, and adiposity-related diseases.