Polydopamine Mediated Metal Organic Frameworks Modification for Improved Biocompatibility.

Engineered nanomaterials are promising in biomedical application. However, insufficient understanding of their biocompatibility at the cellular and organic levels prevents their widely biomedical applications. Metal-organic frameworks (MOFs) have attracted increasing attention in recent years. In this work, zeolite imidazole framework (ZIF-8) and polydopamine (PDA) modified ZIF-8 (ZP) were chosen as model nanomaterials due to its emergent role in nanomedicine. In vitro, the results demonstrated that the PDA coating greatly alleviated the cytotoxicity of ZIF-8 to RAW264.7, LO2 and HST6, which represented three different cell types in liver organs. Mechanistically, ZIF-8 entering into the cells could greatly induce the ROS generation, which subsequently induced cell cycle delay and autophagy, ultimately led to enhanced cytotoxicity. Further, HUEVCs cell model and zebrafish embryos assay also confirmed that PDA could compromise the ZIF-8 toxicity significantly. Our study reveals that PDA coated MOFs nanomaterials show great potential in nano-based drug delivery systems. This article is protected by copyright. All rights reserved.