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From disease modelling to personalised therapy in patients with CEP290 mutations.

Elisa MolinariShalabh SrivastavaJohn Andrew SayerSimon A Ramsbottom
Published in: F1000Research (2017)
Mutations that give rise to premature termination codons are a common cause of inherited genetic diseases. When transcripts containing these changes are generated, they are usually rapidly removed by the cell through the process of nonsense-mediated decay. Here we discuss observed changes in transcripts of the centrosomal protein CEP290 resulting not from degradation, but from changes in exon usage. We also comment on a landmark paper (Drivas et al. Sci Transl Med. 2015) where modelling this process of exon usage may be used to predict disease severity in CEP290 ciliopathies, and how understanding this process may potentially be used for therapeutic benefit in the future.
Keyphrases
  • spinal cord injury
  • single cell
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  • genome wide
  • stem cells
  • gene expression
  • protein protein
  • smoking cessation
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