Evaluation of Neutralizing Antibodies against SARS-CoV-2 Variants after Infection and Vaccination Using a Multiplexed Surrogate Virus Neutralization Test.

Kara L LynchShuxia ZhouRavi KaulRoger WalkerAlan H Wu

Published in: Clinical chemistry (2022)

The plex-sVNT provides a correlative measure to PRNT and a convenient approach for evaluating antibody neutralization against SARS-CoV-2 variants. Neutralization of SARS-CoV-2 variants is reduced compared to wild type and declines over the ensuing months after exposure or vaccination within each cohort, however it is still unknown what degree of neutralizing capacity is protective.

Keyphrases

sars cov
copy number
wild type
respiratory syndrome coronavirus
dengue virus
zika virus
gene expression
genome wide
coronavirus disease