The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.

Annie PuManoj K MishraYifei DongSamira GhorbanigazarErin L StephensonKhalil S RawjiClaudia SilvaHiroshi KitagawaStephen SawcerVoon Wee Yong

Published in: Journal of neuroinflammation (2020)

These results emphasize CSPGs as a prominent modulator of neuroinflammation and they highlight CSPGs accumulating in lesions in promoting axonal injury.

Keyphrases

lipopolysaccharide induced
lps induced
traumatic brain injury
cognitive impairment
cerebral ischemia
spinal cord injury
inflammatory response
subarachnoid hemorrhage
blood brain barrier