High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury - A Potential Mechanism for Obstructive Sleep Apnea with Obesity.

Qingqing ChenXinxin HanMeihua ChenBingjiao ZhaoBingjing SunLiangyan SunWeihua ZhangLiming YuYuehua Liu

Published in: Nature and science of sleep (2021)

Our findings suggest that a HFD caused genioglossus injury in obese mice. The mitochondrial dysfunction and the accompanying oxidative stress were involved in the genioglossus injury, which may provide potential therapeutic targets for OSA with obesity.

Keyphrases

high fat diet induced
insulin resistance
obstructive sleep apnea
oxidative stress
metabolic syndrome
high fat diet
weight loss
positive airway pressure
type diabetes
adipose tissue
skeletal muscle
human health
dna damage
ischemia reperfusion injury
climate change
risk assessment
body mass index
induced apoptosis