Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA.

Kristie BloomHaajira KaldineToni CathomenClaudio MussolinoAbdullah ElyPatrick Arbuthnot

Published in: BMC infectious diseases (2019)

Epigenetic modification of HBV DNA is a new and effective means of inactivating the virus in vivo. The approach has therapeutic potential and avoids potentially problematic unintended mutagenesis of gene editing.

Keyphrases

hepatitis b virus
circulating tumor
cell free
liver failure
single molecule
gene expression
crispr cas
dna methylation
sars cov
nucleic acid
transcription factor
circulating tumor cells
oxidative stress