Overexpression of Cancer Upregulated Gene 2 (CUG2) Decreases Spry2 Through c-Cbl, Leading to Activation of EGFR and β-Catenin Signaling.
Natpaphan YawutChutima KaewpiboonPhatcharaporn BudluangIl-Rae ChoSirichat KaowinnSang Seok KohYoung-Hwa ChungPublished in: Cancer management and research (2020)
CUG2 reduces Spry2 protein levels, the negative signaling molecule of cell proliferation, via c-Cbl, possibly activating the EGFR and β-catenin signaling pathways and, in turn, contributing to the induction of cancer stem cell-like phenotypes.
Keyphrases
- cell proliferation
- cancer stem cells
- small cell lung cancer
- signaling pathway
- epidermal growth factor receptor
- tyrosine kinase
- pi k akt
- papillary thyroid
- cell cycle
- epithelial mesenchymal transition
- squamous cell
- copy number
- genome wide
- sensitive detection
- living cells
- fluorescent probe
- protein protein
- induced apoptosis
- binding protein
- gene expression
- small molecule
- dna methylation