Antiemetic Efficacy of Palonosetron Compared with the Combination of Ondansetron and Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Gynaecological Surgery.
Samarjit DeySairem Mangolnganbi ChanuPriyanka DevManas BorthakurHabib Md Reazaul KarimMd YunusPublished in: Romanian journal of anaesthesia and intensive care (2022)
In group I, 66.67% of the patients had an Apfel score of 2, and 33.33% of the patients had a score of 3. In group II, 85.71% of patients had an Apfel score of 2, and 14.29% of the patients had a score of 3. At 1, 4, and 8 hours, the incidence of PONV was comparable in both groups. At 24 hours there was a significant difference in the incidence of PONV in the group treated with ondansetron with dexamethasone combination (4/42) when compared to the palonosetron group (0/42). The overall incidence of PONV was significantly higher in group I (23.81%: ondansetron and dexamethasone combination) than in group II (7.14%: palonosetron). The need for rescue medication in group I was significantly high. Conclusion: Palonosetron was more efficacious compared to the combination of ondansetron and dexamethasone for preventing PONV for laparoscopic gynaecological surgery.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- patients undergoing
- prognostic factors
- healthcare
- low dose
- minimally invasive
- high dose
- risk factors
- chemotherapy induced
- atrial fibrillation
- percutaneous coronary intervention
- coronary artery disease
- coronary artery bypass
- surgical site infection
- drug induced