Airway Inflammation Before and After Bronchial Thermoplasty in Severe Asthma.

Pieta C WijsmanAnnika W M GoorsenbergAbilash RaviJulia N S d'HoogheBarbara S DierdorpTamara DekkerCharlotte C L M van SchaikNick H T Ten HackenPallav L ShahEls J M WeersinkElisabeth H BelJouke T AnnemaRené LutterPeter I Bonta

Published in: Journal of asthma and allergy (2022)

Local differences in gene sets pertaining to epithelial inflammatory status were identified between treated and untreated airways after treatment, not resulting in changes in differential cell counts and cytokine analyses in BALF. Secondly, baseline epithelial glycolysis genes and eosinophil counts in BALF and blood were different between responders and non-responders. The observations from this study demonstrate the potential impact of BT on epithelial gene expression related to airway inflammation while also identifying a possible responder profile.

Keyphrases

gene expression
genome wide
dna methylation
peripheral blood
genome wide identification
cystic fibrosis
single cell
oxidative stress
cell therapy
copy number