Effect of nintedanib on acute exacerbations of fibrosing interstitial lung diseases: a national database study in Japan.
Hirokazu UrushiyamaTaisuke JoWakae HasegawaAkira YokoyamaTakahiro AndoYukiyo SakamotoRyosuke KumazawaKazuaki UdaNobuaki MichihataNobuyasu AwanoMatsui HirokiKiyohide FushimiHideo YasunagaTakahide NagasePublished in: ERJ open research (2022)
Nintedanib initiation during acute exacerbation was significantly associated with a lower risk of in-hospital death and shorter length of hospitalisation in patients with fibrosing ILDs. Our results elucidate the potential role of nintedanib in the treatment of acute exacerbation in patients with fibrosing ILDs. Further prospective studies are warranted.
Keyphrases
- interstitial lung disease
- respiratory failure
- liver failure
- chronic obstructive pulmonary disease
- idiopathic pulmonary fibrosis
- systemic sclerosis
- aortic dissection
- drug induced
- rheumatoid arthritis
- extracorporeal membrane oxygenation
- cystic fibrosis
- adverse drug
- emergency department
- mechanical ventilation
- quality improvement
- smoking cessation