Sijunzi Decoction Targets IL1B and TNF to Reduce Neutrophil Extracellular Traps (NETs) in Ulcerative Colitis: Evidence from Silicon Prediction and Experiment Validation.
Dong ZhangSiwei DuanZhangyou HeZeming ZhuZhiping LiQincheng YiTiantian CaiJuanjuan LiNan ChenShaoju GuoPublished in: Drug design, development and therapy (2023)
SJZ treats UC by reducing the content of intestinal NETs, with primary targets on the NETs being IL1B and TNFand suppress TNF signal. The practical components of SJZ may be ginsenoside Rh2, isoflavones, and formononetin.
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