Nickel-Catalyzed Double Dehydrogenative Coupling of Secondary Alcohols and β-Amino Alcohols To Access Substituted Pyrroles.
Anitha AlanthadkaSourajit BeraMari VellakkaranDebasis BanerjeePublished in: The Journal of organic chemistry (2019)
Herein, we demonstrate the first nickel-catalyzed double dehydrogenative condensation of secondary alcohols and β-amino alcohols in one pot to the pyrrole derivatives. A series of 2,5- and 2,3,5-substituted pyrroles were obtained in ≤83% yield, releasing water and hydrogen gas as byproducts. Initial mechanistic studies, including defined Ni catalyst, deuterium labeling experiments, quantitative determination of hydrogen gas evaluation, and detection of water generation in the reaction mixture, were performed.
Keyphrases
- room temperature
- ionic liquid
- metal organic framework
- molecular docking
- reduced graphene oxide
- drinking water
- visible light
- carbon dioxide
- oxide nanoparticles
- carbon nanotubes
- molecularly imprinted
- mass spectrometry
- gold nanoparticles
- loop mediated isothermal amplification
- case control
- structure activity relationship