Loss of Smooth Muscle Tenascin-X Inhibits Vascular Remodeling Through Increased TGF-β Signaling.
Guozheng LiangXiao-Fei LvWei HuangYoung-June JinKenneth Anthony RoquidHaruya KawaseStefan OffermannsPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
In summary, TN-X critically regulates VSMC plasticity during vascular injury by inhibiting TGF-β signaling. Our data indicate that inhibition of vascular smooth muscle TN-X may represent a strategy to prevent and treat pathological vascular remodeling.