The cellular protein phosphatase 2A is a crucial host factor for Marburg virus transcription.

Isabel von CreytzCornelius RohdeNadine Biedenkopf

Published in: Journal of virology (2024)

Our study elucidates the crucial role of host protein phosphatase 2A (PP2A) in Marburg virus (MARV) transcription. The regulatory subunit B56 of PP2A facilitates VP30 dephosphorylation, and hence transcription activation, via binding to NP. Our results, together with previous data, reveal a conserved mechanism of filovirus VP30 dephosphorylation by host factor PP2A at the NP interface and provide novel insights into potential pan-filovirus therapies.

Keyphrases

transcription factor
disease virus
protein kinase
protein protein
amino acid
binding protein
single cell
gene expression
human health
deep learning
artificial intelligence