Endocrine disruption: In silico perspectives of interactions of di-(2-ethylhexyl)phthalate and its five major metabolites with progesterone receptor.

Ishfaq A SheikhMuhammad Abu-ElmagdRola F TurkiGhazi A DamanhouriMohd A BegMohammed Al-Qahtani

Published in: BMC structural biology (2016)

The high binding affinity of DEHP and its five major metabolites with PR as well as a high rate of overlap between PR interacting residues among DEHP and its metabolites and the native ligand, NET, suggested their disrupting potential in normal PR signaling, resulting in adverse reproductive effects.

Keyphrases

ms ms
molecular docking
emergency department
risk assessment
escherichia coli
dna binding
pseudomonas aeruginosa
cystic fibrosis
protein kinase
mass spectrometry
human health
biofilm formation
transcription factor
adverse drug