Safety of Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized Trials Involving More than 8,000 Patients.

Larry E MillerSamir BhattacharyyaWilliam R ParrishMichael FredericsonBrad BissonRoy D Altman

Published in: Cartilage (2019)

IAHA was shown to be safe for use in patients with symptomatic knee OA. Compared with IA saline, IAHA is associated with an increased risk of nonserious, transient local reactions. There was no evidence to suggest any additional safety risks of IAHA.

Keyphrases

knee osteoarthritis
hyaluronic acid
end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
total knee arthroplasty
risk assessment
climate change
subarachnoid hemorrhage
patient reported